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What is SubSema?

SubSema is a compounded sublingual Semaglutide, a needle-free delivery mechanism and solution taken by oral syringe that is dispensed under the tongue. It is created with a new to the market base, called SubMagna. This base is a liquid solution, that has a high molecular weight, meaning it has a high absorption rate.

Benefits of SubSema

  • Needle-free: SubSema offers enhanced comfort and accessibility for patients.
  • High absorption rate: SubSema has efficient delivery and 30x more absorption than commercial Semaglutide.
  • In stock: SubSema is a new product to the market that Preston’s Pharmacy has available!
  • Successful: SubSema includes the already successful Semaglutide drug.
  • Tastes good: SubSema includes a mint flavor, similar to a toothpaste flavor.
  • Adhesive: SubSema allows increased contact.

How to Use

  1. Drop solution under the tongue
  2. Hold for 90 seconds, then swallow
  3. Do not eat or drink for 30 minutes after


1mg/mL in a 30mL bottle

Initial dose is 0.3mL once daily for 7 days, then titrate up to 0.5mL once daily thereafter. The 30mL bottle should last about 60 days.

SubSema at Preston’s Pharmacy

Preston’s Pharmacy is one of the first to compound this groundbreaking addition to the market, with SubSema fully in stock! A cost effective alternative, at $200 for 60 day supply. Call Preston’s Compounding at (571) 341-8787 or email